Job Description

Job Summary

The Helms Laboratory in the Department of Internal Medicine, Division of Cardiovascular Medicine, at the University of Michigan is seeking a postdoctoral research fellow to join our interdisciplinary team focused on genetic cardiomyopathy, particularly hypertrophic and arrhythmogenic cardiomyopathy subtypes. We utilize both iPSC-derived cardiomyocyte and mouse models. We generate gene-edited, reporter knock-in, and patient-derived iPSC lines. We work closely with biomedical engineering collaborators and utilize a range of tools for assessing iPSC-CMs, including a muscle bundle platform we developed to increase rigor of structure-function quantifications. We also perform CRISPRa high throughput screening and massively parallel reporter assays (MPRAs) in iPSC-CMs. A current major focus of the lab is implementation of MPRAs to decode and harness noncoding variant contributors to cardiomyopathy. We have also developed two new mouse models for translational discovery and testing of gene therapy approaches (novel haploinsufficient models of MYBPC3 hypertrophic cardiomyopathy and DSP arrhythmogenic cardiomyopathy that recapitulate the human diseases). The postdoctoral fellow will have opportunities to take projects with them to their independent position.  
 

Lab website: https://sites.google.com/umich.edu/helmslab 
 

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

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Being part of something greater, of serving a larger mission of discovery and care — that's the heart of what drives people to work at Michigan. In some way, great or small, every person here helps to advance this world-class institution. It's adding a purpose to your profession. Work at Michigan and become a victor for the greater good.

Responsibilities*

Required Qualifications*

Desired Qualifications*

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.

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